Assessment of iron Parameters and Transient Elastography (FibroScan) Pattern amongPatients with Chronic Viral Hepatitis Infection in Jos, Nigeria

  • AkinolaOyekemi I Department of Haematology and Blood Transfusion, Jos University Teaching Hospital, Jos, Plateau State, Nigeria
  • Salawu Lateef Department of Haematology and Blood Transfusion, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria
  • EgesieOchaka J Department of Haematology and Blood Transfusion, Jos University Teaching Hospital, Jos, Plateau State, Nigeria
  • Okeke Edith N Department of Internal Medicine, Jos University Teaching Hospital, Jos, Plateau State, Nigeria
  • Damulak Obadiah D Department of Haematology and Blood Transfusion, Jos University Teaching Hospital, Jos, Plateau State, Nigeria
  • Imoh Lucius C Department of Chemical Pathology, Jos University Teaching Hospital, Jos, Plateau State, Nigeria
  • Akor Emmanuel A Department of Haematology and Blood Transfusion, Jos University Teaching Hospital, Jos, Plateau State, Nigeria

Abstract

Background:The long-termeffect of excess iron deposition in the liver include fibrosis and cirrhosis which may progress to hepatocellular carcinoma. We assessed iron parameters among patients with chronic viral hepatitis B and C infection (CVHBI; CVHCI) to determineif any correlation existed with the degree of fibrosis in the liver.

Methods: A cross-sectional descriptive study was carried out on 186 patients, made up of 132 patients withCVHBI and 54 patients with CVHCI. Serum ferritin and C-reactive protein were done by ELISA, serum iron and total iron binding capacity (TIBC) by colorimetric technique while transferrin saturation (Tsat) was calculated using serum iron and TIBC values. Liver fibrosis was assessed using fibroscan.Obtained data wereanalysed using SPSS version 20 and p values < 0.05 were considered statistically significant. 

Results: The mean values for serum ferritin, iron, TIBC and Tsat were 218.1±325.6µg/L, 25.1±22.8µmol/L, 71.13 ± 35.92µmol/L and 45.2 ± 49.9% respectively. There were no significant differences in iron parameters between patients with CVHBI and CVHCI. Elevated serum ferritin was found in 15.2% and 20.4% of CHBVI and CHCVI patients respectively; while an elevated Tsat was seen in 22.7% and 24.1% of CHBVI and CHCVI patients respectively. Using a combination of elevated serum ferritin and Tsat, the prevalence of iron overload was found to be1.6%. Fibroscan scores did not differ significantly between patients with orwithout elevated iron parameters.

Conclusion:Chronic viral hepatitis infection is associated elevated iron parameters though withminimal effect on liver fibrosis.

Conflict of interest: Nil

Published
2019-03-28
How to Cite
I, A., Lateef, S., J, E., N, O., D, D., C, I., & A, A. (2019). Assessment of iron Parameters and Transient Elastography (FibroScan) Pattern amongPatients with Chronic Viral Hepatitis Infection in Jos, Nigeria. Journal of Medical Care Research and Review, 2(03), 01-05. Retrieved from http://jmcrr.in/index.php/jmcrr/article/view/35
Section
Articles